Core Testing - DHA Laboratory

Kryptopyrrole Analysis

“Pyroluria is frequently identified in behavior disorders, Autism, Asperger’s, ADHD, ADD, depression, aggressive/violent behavior, and schizophrenia.”

The kryptopyrrole quantitative urine kit is a noninvasive biomarker that’s used to accurately determine oxidative stress risk and the production of dopamine and norepinephrine by its connection specifically to zinc and B6. The pyrrole analysis itself is measuring HPL or hydroxyhemopyrrolin-2-one, a byproduct of hemoglobin synthesis.

When overproduced, the body naturally excretes it, but it has an affinity for zinc and B6. If you work with patients or clients who suffer from mental or emotional conditions, or symptoms that relate to dopamine production or norepinephrine production, it’s essential to check for pyrrole disorder. It’s a non-invasive and cost effective test that gets right to the root cause.

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Methylation Status

“Abnormalities in methylation and folate chemistry are common in schizophrenia, bipolar disorder, depression, anxiety and other behavioral disorders.”

More than two-thirds of persons diagnosed with a behavior or mental disorder exhibit a methylation imbalance, as the methyl chemical is necessary for turning on dozens of neurotransmitters. Among the ways to analyze methylation status, we use whole blood histamine because it provides the optimal over and under numerical value. That quantitative value can be remeasured to determine effectiveness of treatment after retesting, unlike other commonly used methods like the MTHFR gene or methylation profile plasmas that show SAM SAH ratio.

Correcting genetic or acquired imbalances in methyl and folate levels have resulted in thousands of reports of improved improvement in patients affected by psychosis, depression, anxiety, and other illnesses.

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Copper/Zinc Ratio and % of Free Copper

“Zinc deficiency is by far the most frequently observed chemical imbalance in mental health populations. More than 90% of persons diagnosed with depression, behavioral disorders, ADHD, autism and schizophrenia exhibit depleted plasma zinc levels, ranging from low-normal to severe deficiency.” [1]

Zinc deficiency has been associated with delayed growth, temper control problems, poor immune function, depression, poor wound healing, epilepsy, anxiety, neurodegenerative disorders, hormone imbalances, and learning problems.

Copper overload is present in most cases of hyperactivity, learning disability, postpartum depression, autism, and paranoid schizophrenia. Nutrient therapy to normalize copper levels can be effective in balancing dopamine and norepinephrine levels in persons suffering from mental illness.

Most persons with elevated blood copper also exhibit depressed zinc and excessive oxidative stress. Personality disorders usually involve the combination of zinc deficiency, oxidative overload, undermethylation, and elevated toxic metals.

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Why Work with DHA Laboratory:

Providers love to partner with DHA because we’re on a cohesive mission together to provide evidence-based laboratory testing to patients and clients, while offering them support through simple, fluid ordering processes. Whether you’re in office and sending your patient or client to a collection site, you are collecting on-site, or work completely virtually and drop ship to clients…we take care of it.

Any laboratory can offer and process the same markers, but there comes variety between the 11 different types of copper tests and 10 different types of zinc tests. DHA ensures the collection process, the tubes used and the exact laboratory procedure, is of the highest standard, the gold standard.

Utilizing the right testing process that correlates with the leading research is a requirement for our laboratory, so that physicians and providers can interpret findings functionally to then use in clinical consultations.

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[1] Quotes excerpted from Nutrient Power: Heal Your Biochemistry and Heal Your Brain, by William J. Walsh, PhD