**Note: All laboratory testing requires an authorizing physician. DHA Laboratory offers a patient direct program that partners you with an authorizing physician. If you have any additional questions regarding the availability of testing, please contact our laboratory by telephone or email.**
This test is used for the measurement of histamine in plasma. Histamine is a central mediator of allergic response. Exposure of sensitized individuals to allergens triggers histamine release by basophil and mast cells. Histamine binds to specific receptors on smooth muscle cells and provokes potent adverse effects. Histamine concentration in biological fluids is correlated with the severity of vascular and respiratory signs of anaphylaxis. Histamine quantification has been used to confirm that clinical signs result from the degranulation of mast cells and/or basophils.