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Lab Testing

SAMe/SAH Methylation Profile Plasma

Doctors Data

SKU: 3737


Product Description

**Note: All laboratory testing requires an authorizing physician. DHA Laboratory offers a patient direct program that partners you with an authorizing physician. If you have any additional questions regarding the availability of testing, please contact our laboratory by telephone or email.**

The SAMe/SAH Methylation Profile provides a functional assessment by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine and cystathionine. In addition, this test provides the important “methylation index,” a ratio of SAM to SAH.

The methylation profile tests for:

  • Cystathionine
  • Cysteine
  • Homocysteine
  • Methionine
  • SAM
  • SAH
  • SAM, SAH ratio

Stable metabolism of methionine is very important for cellular methylation of DNA, proteins, and neurotransmitters.  Abnormal methionine metabolism may appear in anyone at any age. Usually associated with genetic/nutritional deficiencies, exposure to environmental toxins, and aging. Furthermore it is linked with a variety of symptoms such as cancer and cardiovascular disease.

The methylation profile test can be ordered due to the following conditions:

  • Neurodegenerative diseases
  • Autism
  • Oxidative stress
  • Cardiovascular disease
  • Schizophrenia
  • Bipolar disease
  • Cancer
  • Global under-methylation

Trained physicians will often order the methylation profile test to refine the results from a whole blood histamine test for treatment of methylation.

By evaluating the plasma levels of cysteine, methionine, SAM, SAH, homocysteine and cystathionine, the methylation profile allows for a ratio of SAM to SAH also known as “methylation index” to be calculated. Test results will guide trained physicians on how to provide nutritional support to improve/normalize methionine metabolism therefore improving or preventing adverse conditions linked with inadequate methylation.


Instructions (PDF)
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Sample Report

Sample Report (PDF)
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