Methylation Profile Plasma (SAMe/SAH) - DHA Laboratory

Lab Testing


Methylation Profile Plasma (SAMe/SAH)

Doctor's Data

SKU: 3737


Product Description

**Note: All laboratory testing requires an authorizing physician. DHA Laboratory offers a Patient Direct Program that partners you with an authorizing physician. If you have any additional questions regarding the availability of testing, please contact our laboratory by telephone or email.**


SAMe/SAH Methylation Profile Plasma


The SAMe/SAH Methylation Profile provides a functional assessment by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine, and cystathionine. In addition, this test provides the important “methylation index,” a ratio of SAM to SAH.

The methylation profile tests for:

  • Cystathionine
  • Cysteine
  • Homocysteine
  • Methionine
  • SAM
  • SAH
  • SAM, SAH ratio

The stable metabolism of methionine is very important for the cellular methylation of DNA, proteins, and neurotransmitters. Abnormal methionine metabolism may appear in anyone at any age. Usually associated with genetic/nutritional deficiencies, exposure to environmental toxins, and aging. Furthermore, it is linked with a variety of symptoms such as cancer and cardiovascular disease.

The methylation profile test can be ordered due to the following conditions:

  • Neurodegenerative diseases
  • Autism
  • Oxidative stress
  • Cardiovascular disease
  • Schizophrenia
  • Bipolar disease
  • Cancer
  • Global under-methylation

Trained physicians will often order the methylation profile test to refine the results from a whole blood histamine test for the treatment of methylation.

By evaluating the plasma levels of cysteine, methionine, SAM, SAH, homocysteine, and cystathionine, the methylation profile allows for a ratio of SAM to SAH also known as “methylation index” to be calculated. Test results will guide trained physicians on how to provide nutritional support to improve/normalize methionine metabolism, therefore, improving or preventing adverse conditions linked with inadequate methylation.


Performing Laboratory is Doctor’s Data.

Please note that the SAMe/SAH Methylation Profile Plasma test requires a blood draw. There will be additional blood draw fees associated with the specimen collection from the local laboratory/clinic that performs the draw.


Instructions (PDF)
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Sample Report

Sample Report (PDF)
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Have Questions? Contact us and we can help!