**Note: All laboratory testing requires an authorizing physician. DHA Laboratory offers a patient direct program that partners you with an authorizing physician. If you have any additional questions regarding the availability of testing, please contact our laboratory by telephone or email.**
The SAMe/SAH Methylation Profile provides a functional assessment by evaluating the plasma levels of methionine, cysteine, SAM, SAH, homocysteine and cystathionine. In addition, this test provides the important “methylation index,” a ratio of SAM to SAH.
The methylation profile tests for:
Stable metabolism of methionine is very important for cellular methylation of DNA, proteins, and neurotransmitters. Abnormal methionine metabolism may appear in anyone at any age. Usually associated with genetic/nutritional deficiencies, exposure to environmental toxins, and aging. Furthermore it is linked with a variety of symptoms such as cancer and cardiovascular disease.
The methylation profile test can be ordered due to the following conditions:
Trained physicians will often order the methylation profile test to refine the results from a whole blood histamine test for treatment of methylation.
By evaluating the plasma levels of cysteine, methionine, SAM, SAH, homocysteine and cystathionine, the methylation profile allows for a ratio of SAM to SAH also known as “methylation index” to be calculated. Test results will guide trained physicians on how to provide nutritional support to improve/normalize methionine metabolism therefore improving or preventing adverse conditions linked with inadequate methylation.