**NOTE: All laboratory testing requires an authorizing physician in order to complete the laboratory testing.**
Levels of SHBG are under positive control of estrogens and thyroid hormones, and are suppressed by androgens. These influences control the liver synthesis of this carrier protein. Decreased levels of SHBG are often found in hirsutism, virilization, obese postmenopausal women, and in women with prevalent hair loss. Increased levels are sometimes present in cases of hyperthyroidism, testicular feminization, cirrhosis, male hypogonadism, pregnancy, women using oral contraceptives, and prepubertal children.
This test requires a blood draw